Liverpool, riding high as Premier League leaders and Europa League knockout stage participants, host rivals Manchester United at a low point as Erik ten Hag's side travel to Anfield. 

United are under pressure, having been knocked out of Europe entirely after a 1-0 midweek defeat to Bayern Munich left them bottom of their Champions League group. It's the first time they have been dumped from continental action in such a fashion since 2005.

On the other hand, Liverpool are top of the Premier League table with 37 points after 16 games, a point above Arsenal in second and two on Aston Villa in third. 

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Liverpool: 1.37
Draw: 6.02
Manchester United: 8.25

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United will be looking for revenge from the memorable 7-0 defeat last time these two met at this venue, in which Cody Gakpo, Darwin Nunez, and Mohamed Salah all bagged braces for the Reds in the runaway victory.

It's impossible to back Manchester United to get a result at Anfield so soon after being humbled in the Champions League and there's nothing to suggest a turnaround at this stage.

Prediction 

While the market seems to favor Liverpool to humiliate Manchester United for the second straight meeting, that's not as likely to occur as it may seem. There's plenty of reason to believe this match will be a lower scoring affair than expected. 

Manchester United's defensive unit has been porous all season, especially when Raphael Varane is not playing, but with the injuries to Ten Hag's side, it may force his hand for the second straight match, with no choice but to play the French defender – as he did against Bayern Munich.

Given Varane's likely participation, coupled with the suspension of United's most creative player Bruno Fernandes, it's hard to imagine either team really letting it fly.

Liverpool 3-1 Manchester United 

Predicted Line-ups 

Liverpool: Alisson; Alexander-Arnold, Konate, Van Dijk, Tsimikas; Endo, Jones, Szoboszlai; Salah, Nunez, Diaz

Manchester United: Onana, Wan-Bissaka, Varane, Lindelof, Dalot — McTominay, Amrabat, Mainoo — Antony, Hojlund, Garnacho.

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Premier League Gameweek 17 Predictions: Liverpool To Humiliate Man Utd

Mentions: Liverpool Manchester United Jurgen Klopp Erik ten Hag